HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions

To clarify E1^E4’s role during high-risk HPV infection, the E4 proteins of HPV16 and 18 were compared side by side using an isogenic keratinocyte differentiation model. While no effect on cell proliferation or viral genome copy number was observed during the early phase of either virus life cycle, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Egawa, Nagayasu, Wang, Qian, Griffin, Heather M., Murakami, Isao, Jackson, Deborah, Mahmood, Radma, Doorbar, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371391/
https://www.ncbi.nlm.nih.gov/pubmed/28306742
http://dx.doi.org/10.1371/journal.ppat.1006282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371391/
https://www.ncbi.nlm.nih.gov/pubmed/28306742
http://dx.doi.org/10.1371/journal.ppat.1006282

Ejemplares similares