Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70

[Image: see text] HSP70 is a molecular chaperone and a key component of the heat-shock response. Because of its proposed importance in oncology, this protein has become a popular target for drug discovery, efforts which have as yet brought little success. This study demonstrates that adenosine-deriv...

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Detalles Bibliográficos
Autores principales: Cheeseman, Matthew D., Westwood, Isaac M., Barbeau, Olivier, Rowlands, Martin, Dobson, Sarah, Jones, Alan M., Jeganathan, Fiona, Burke, Rosemary, Kadi, Nadia, Workman, Paul, Collins, Ian, van Montfort, Rob L. M., Jones, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371393/
https://www.ncbi.nlm.nih.gov/pubmed/27119979
http://dx.doi.org/10.1021/acs.jmedchem.5b02001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371393/
https://www.ncbi.nlm.nih.gov/pubmed/27119979
http://dx.doi.org/10.1021/acs.jmedchem.5b02001

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