Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation

Multiple pathogens, including viruses and bacteria, manipulate endoplasmic reticulum-associated degradation (ERAD) to avoid the host immune response and promote their replication. The betaretrovirus mouse mammary tumor virus (MMTV) encodes Rem, which is a precursor protein that is cleaved into a 98-...

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Detalles Bibliográficos
Autores principales: Byun, Hyewon, Das, Poulami, Yu, Houqing, Aleman, Alejandro, Lozano, Mary M., Matouschek, Andreas, Dudley, Jaquelin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371415/
https://www.ncbi.nlm.nih.gov/pubmed/28351922
http://dx.doi.org/10.1128/mBio.00328-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371415/
https://www.ncbi.nlm.nih.gov/pubmed/28351922
http://dx.doi.org/10.1128/mBio.00328-17

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