Sepiapterin reductase gene‐disrupted mice suffer from hypertension with fluctuation and bradycardia

(6R)‐l‐erythro‐5,6,7,8‐Tetrahydrobiopterin (BH4) is an essential cofactor for monoamine and nitric oxide (NO) production. Sepiapterin reductase (SPR) catalyzes the final step in BH4 biosynthesis. We analyzed the cardiovascular function of adult Spr gene‐disrupted (Spr (−/−)) mice for the first time....

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Detalles Bibliográficos
Autores principales: Sumi‐Ichinose, Chiho, Suganuma, Yui, Kano, Taiki, Ihira, Noriko, Nomura, Hiroko, Ikemoto, Kazuhisa, Hata, Tadayoshi, Katoh, Setsuko, Ichinose, Hiroshi, Kondo, Kazunao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371564/
https://www.ncbi.nlm.nih.gov/pubmed/28320892
http://dx.doi.org/10.14814/phy2.13196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371564/
https://www.ncbi.nlm.nih.gov/pubmed/28320892
http://dx.doi.org/10.14814/phy2.13196

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