Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases

Bile acid (BA) receptors represent well-defined targets for the development of novel therapeutic approaches to metabolic and inflammatory diseases. In the present study, we report the generation of novel C-3 modified 6-ethylcholane derivatives. The pharmacological characterization and molecular dock...

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Detalles Bibliográficos
Autores principales: Festa, Carmen, De Marino, Simona, Carino, Adriana, Sepe, Valentina, Marchianò, Silvia, Cipriani, Sabrina, Di Leva, Francesco S., Limongelli, Vittorio, Monti, Maria C., Capolupo, Angela, Distrutti, Eleonora, Fiorucci, Stefano, Zampella, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371667/
https://www.ncbi.nlm.nih.gov/pubmed/28424617
http://dx.doi.org/10.3389/fphar.2017.00162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371667/
https://www.ncbi.nlm.nih.gov/pubmed/28424617
http://dx.doi.org/10.3389/fphar.2017.00162

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