The Spontaneous Autoimmune Neuromyopathy in ICOSL(−/−) NOD Mice Is CD4(+) T-Cell and Interferon-γ Dependent

Abrogation of ICOS/ICOS ligand (ICOSL) costimulation prevents the onset of diabetes in the non-obese diabetic (NOD) mouse but, remarkably, yields to the development of a spontaneous autoimmune neuromyopathy. At the pathological level, ICOSL(−/−) NOD mice show stronger protection from insulitis than...

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Detalles Bibliográficos
Autores principales: Briet, Claire, Bourdenet, Gwladys, Rogner, Ute C., Becourt, Chantal, Tardivel, Isabelle, Drouot, Laurent, Arnoult, Christophe, do Rego, Jean-Claude, Prevot, Nicolas, Massaad, Charbel, Boyer, Olivier, Boitard, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371727/
https://www.ncbi.nlm.nih.gov/pubmed/28424681
http://dx.doi.org/10.3389/fimmu.2017.00287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371727/
https://www.ncbi.nlm.nih.gov/pubmed/28424681
http://dx.doi.org/10.3389/fimmu.2017.00287

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