Personal model‐assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD

To elucidate the molecular mechanisms underlying non‐alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes and used these individual measurements as personalized constraints of a hepatocyte...

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Detalles Bibliográficos
Autores principales: Mardinoglu, Adil, Bjornson, Elias, Zhang, Cheng, Klevstig, Martina, Söderlund, Sanni, Ståhlman, Marcus, Adiels, Martin, Hakkarainen, Antti, Lundbom, Nina, Kilicarslan, Murat, Hallström, Björn M, Lundbom, Jesper, Vergès, Bruno, Barrett, Peter Hugh R, Watts, Gerald F, Serlie, Mireille J, Nielsen, Jens, Uhlén, Mathias, Smith, Ulf, Marschall, Hanns‐Ulrich, Taskinen, Marja‐Riitta, Boren, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371732/
https://www.ncbi.nlm.nih.gov/pubmed/28254760
http://dx.doi.org/10.15252/msb.20167422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371732/
https://www.ncbi.nlm.nih.gov/pubmed/28254760
http://dx.doi.org/10.15252/msb.20167422

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