Functional Contributions of Positive Charges in the Pore-Lining Helix 3 of the Bordetella pertussis CyaA-Hemolysin to Hemolytic Activity and Ion-Channel Opening

The Bordetella pertussis CyaA-hemolysin (CyaA-Hly) domain was previously demonstrated to be an important determinant for hemolysis against target erythrocytes and ion-channel formation in planar lipid bilayers (PLBs). Here, net-charge variations in the pore-lining helix of thirteen related RTX cytol...

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Detalles Bibliográficos
Autores principales: Kurehong, Chattip, Kanchanawarin, Chalermpol, Powthongchin, Busaba, Prangkio, Panchika, Katzenmeier, Gerd, Angsuthanasombat, Chanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371864/
https://www.ncbi.nlm.nih.gov/pubmed/28300777
http://dx.doi.org/10.3390/toxins9030109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371864/
https://www.ncbi.nlm.nih.gov/pubmed/28300777
http://dx.doi.org/10.3390/toxins9030109

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