Domain-specific interactions between MLN8237 and human serum albumin estimated by STD and WaterLOGSY NMR, ITC, spectroscopic, and docking techniques

Alisertib (MLN8237) is an orally administered inhibitor of Aurora A kinase. This small-molecule inhibitor is under clinical or pre-clinical phase for the treatment of advanced malignancies. The present study provides a detailed characterization of the interaction of MLN8237 with a drug transport pro...

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Detalles Bibliográficos
Autores principales: Yang, Hongqin, Liu, Jiuyang, Huang, Yanmei, Gao, Rui, Tang, Bin, Li, Shanshan, He, Jiawei, Li, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371984/
https://www.ncbi.nlm.nih.gov/pubmed/28358124
http://dx.doi.org/10.1038/srep45514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371984/
https://www.ncbi.nlm.nih.gov/pubmed/28358124
http://dx.doi.org/10.1038/srep45514

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