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Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo
BACKGROUND: Astrocyte activation is a hallmark of traumatic brain injury resulting in neurological dysfunction or death for an overproduction of inflammatory cytokines and glial scar formation. Both the silent mating type information (Sirt1) expression and mitogen-activated protein kinase (MAPK) sig...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372348/ https://www.ncbi.nlm.nih.gov/pubmed/28356158 http://dx.doi.org/10.1186/s12974-017-0841-6 |