Cargando…

Mechanistic prediction of food effects for Compound A tablet using PBPK model

Physiologically based pharmacokinetic (PBPK) modeling has been extensively used to study the factors of effect drug absorption, distribution, metabolize and extraction progress in human. In this study, Compound A(CPD A) is a BCS Class II drug, which has been extensive applied in clinical as lipid-lo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xueqing, Shi, Lei, Tang, Xiuling, Wang, Qinghui, Zhou, Lun, Song, Wei, Feng, Zhijun, Ge, Jie, Li, Jian Kang, Yang, Lin, Wen, Aidong, Zhang, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372427/ https://www.ncbi.nlm.nih.gov/pubmed/28386186 http://dx.doi.org/10.1016/j.sjbs.2017.01.032

Ejemplares similares

Formulation development, in vivo bioequivalence and pediatric PBPK modeling studies of taste-masked ciprofloxacin chewable tablets
por: Usmani, Muhammad Talha, et al.
Publicado: (2023)

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
por: Kuepfer, L, et al.
Publicado: (2016)

Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population
por: Li, Xueqing, et al.
Publicado: (2017)

Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator
por: Ezuruike, Udoamaka, et al.
Publicado: (2022)

Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents
por: Chirumamilla, Siri Kalyan, et al.
Publicado: (2021)

Mechanistic evaluation of the inhibitory effect of four SGLT-2 inhibitors on SGLT 1 and SGLT 2 using physiologically based pharmacokinetic (PBPK) modeling approaches
por: Zhang, Yu, et al.
Publicado: (2023)

A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds
por: Liu, Rongrui, et al.
Publicado: (2022)

Novel Mechanistic PBPK Model to Predict Renal Clearance in Varying Stages of CKD by Incorporating Tubular Adaptation and Dynamic Passive Reabsorption
por: Huang, Weize, et al.
Publicado: (2020)

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK
por: Wagner, C, et al.
Publicado: (2015)

Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans
por: Chen, Yu-Luan, et al.
Publicado: (2023)

Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective
por: Riedmaier, Arian Emami, et al.
Publicado: (2020)

Prediction of Pharmacokinetics and Penetration of Moxifloxacin in Human with Intra-Abdominal Infection Based on Extrapolated PBPK Model
por: Zhu, LiQin, et al.
Publicado: (2015)

PBPK modeling and simulation in drug research and development
por: Zhuang, Xiaomei, et al.
Publicado: (2016)

A Workflow for Global Sensitivity Analysis of PBPK Models
por: McNally, Kevin, et al.
Publicado: (2011)

PBPK Modeling on Organs-on-Chips: An Overview of Recent Advancements
por: Yang, Yi, et al.
Publicado: (2022)

Permeability of Gemcitabine and PBPK Modeling to Assess Oral Administration
por: Ferreira, Abigail, et al.
Publicado: (2021)

Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects
por: Cui, Cheng, et al.
Publicado: (2021)

Bioequivalence study of ipratropium bromide inhalation aerosol using PBPK modelling
por: Zhang, Jisheng, et al.
Publicado: (2023)

Incorporating Target Shedding Into a Minimal PBPK–TMDD Model for Monoclonal Antibodies
por: Li, L, et al.
Publicado: (2014)

PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human
por: Campbell, Jerry L., et al.
Publicado: (2016)

Where Do PBPK Models Stand in Pharmacometrics and Systems Pharmacology?
por: Jamei, Masoud
Publicado: (2020)

Current PBPK Models: Are They Predicting Tissue Drug Concentration Correctly?
por: Ibarra, Manuel, et al.
Publicado: (2020)

PBPK model reporting template for chemical risk assessment applications
por: Tan, Yu-Mei, et al.
Publicado: (2020)

PBPK Modelling of Dexamethasone in Patients With COVID-19 and Liver Disease
por: Montanha, Maiara Camotti, et al.
Publicado: (2022)

PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes
por: Levitt, David G.
Publicado: (2018)

Complex Mixtures: Array PBPK Modeling of Jet Fuel Components
por: Sterner, Teresa R., et al.
Publicado: (2023)

Alternol/Alteronol: Potent Anti-cancer Compounds With Multiple Mechanistic Actions
por: Liu, Wang, et al.
Publicado: (2020)

Quality Assurance of PBPK Modeling Platforms and Guidance on Building, Evaluating, Verifying and Applying PBPK Models Prudently under the Umbrella of Qualification: Why, When, What, How and By Whom?
por: Frechen, Sebastian, et al.
Publicado: (2022)

Reproducing prolonged time to peak bisoprolol concentration by PBPK modeling with lysosomal trapping in enterocytes
por: Wu, Dan‐Na, et al.
Publicado: (2022)

Statistical analysis of Fisher et al. PBPK model of trichloroethylene kinetics.
por: Bois, F Y
Publicado: (2000)

Statistical analysis of Clewell et al. PBPK model of trichloroethylene kinetics.
por: Bois, F Y
Publicado: (2000)

Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats
por: Cuello, W. S., et al.
Publicado: (2012)

PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water
por: Breckenridge, Charles B., et al.
Publicado: (2016)

Analysis of biomarker utility using a PBPK/PD model for carbaryl
por: Phillips, Martin B., et al.
Publicado: (2014)

Current Approaches and Techniques in Physiologically Based Pharmacokinetic (PBPK) Modelling of Nanomaterials
por: Utembe, Wells, et al.
Publicado: (2020)

Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development
por: Shaik, Abdul Naveed, et al.
Publicado: (2019)

Editorial: Exploring Maternal-Fetal Pharmacology Through PBPK Modeling Approaches
por: Dallmann, André, et al.
Publicado: (2022)

PBPK perspective on alternative CYP3A4 inducers for rifampin
por: Chen, Kuan‐Fu, et al.
Publicado: (2022)

Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models
por: Denninger, Alexander, et al.
Publicado: (2023)

Development of a PBPK model to quantitatively understand absorption and disposition mechanism and support future clinical trials for PB‐201
por: Zhang, Miao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qliqtedunha3dbooa46thnlb1b