Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts

Hyperglycemia results in accumulation of the reactive dicarbonyl methylglyoxal (MG). Methylglyoxal is detoxified by the glyoxalase system (glyoxalase 1 and 2). The influence of glyoxalase 1 knockdown on expression of collagens 1, 3, 4, and 5 in L6 myoblasts under hyperglycemic conditions was investi...

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Detalles Bibliográficos
Autores principales: Stratmann, Bernd, Goldstein, Bernhard, Thornalley, Paul J., Rabbani, Naila, Tschoepe, Diethelm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372496/
https://www.ncbi.nlm.nih.gov/pubmed/28241483
http://dx.doi.org/10.3390/ijms18030480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372496/
https://www.ncbi.nlm.nih.gov/pubmed/28241483
http://dx.doi.org/10.3390/ijms18030480

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