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TNFα Increases RANKL Expression via PGE(2)-Induced Activation of NFATc1

Tumor necrosis factor α (TNFα) is known to upregulate the expression of receptor activator of NF-κB ligand (RANKL). We investigated the role of the calcineurin/nuclear factor of activated T-cells (NFAT) signaling pathway in TNFα-induced RANKL expression in C2C12 and primary cultured mouse calvarial...

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Detalles Bibliográficos
Autores principales: Park, Hyun-Jung, Baek, Kyunghwa, Baek, Jeong-Hwa, Kim, Hyung-Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372511/
https://www.ncbi.nlm.nih.gov/pubmed/28245593
http://dx.doi.org/10.3390/ijms18030495