Structural Basis of Native CXCL7 Monomer Binding to CXCR2 Receptor N-Domain and Glycosaminoglycan Heparin

CXCL7, a chemokine highly expressed in platelets, orchestrates neutrophil recruitment during thrombosis and related pathophysiological processes by interacting with CXCR2 receptor and sulfated glycosaminoglycans (GAG). CXCL7 exists as monomers and dimers, and dimerization (~50 μM) and CXCR2 binding...

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Detalles Bibliográficos
Autores principales: Brown, Aaron J., Sepuru, Krishna Mohan, Rajarathnam, Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372524/
https://www.ncbi.nlm.nih.gov/pubmed/28245630
http://dx.doi.org/10.3390/ijms18030508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372524/
https://www.ncbi.nlm.nih.gov/pubmed/28245630
http://dx.doi.org/10.3390/ijms18030508

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