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Proline Residues as Switches in Conformational Changes Leading to Amyloid Fibril Formation

Here we discuss studies of the structure, folding, oligomerization and amyloid fibril formation of several proline mutants of human stefin B, which is a protein inhibitor of lysosomal cysteine cathepsins and a member of the cystatin family. The structurally important prolines in stefin B are respons...

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Detalles Bibliográficos
Autores principales: Taler-Verčič, Ajda, Hasanbašić, Samra, Berbić, Selma, Stoka, Veronika, Turk, Dušan, Žerovnik, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372565/
https://www.ncbi.nlm.nih.gov/pubmed/28272335
http://dx.doi.org/10.3390/ijms18030549