Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth via Upregulation of STAT1, p53, and Bax and Downregulation of c-Myc and Bcl-2

GlyoxalaseI (GLOI) is an enzyme that catalyzes methylglyoxal metabolism. Overexpression of GLOI has been documented in numerous tumor tissues, including colorectal cancer (CRC). The antitumor effects of GLOI depletion have been demonstrated in some types of cancer, but its role in CRC and the mechan...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yuan, Fang, Lei, Zhang, Jiali, Li, Gefei, Ma, Mengni, Li, Changxi, Lyu, Jianxin, Meng, Qing H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372586/
https://www.ncbi.nlm.nih.gov/pubmed/28282916
http://dx.doi.org/10.3390/ijms18030570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372586/
https://www.ncbi.nlm.nih.gov/pubmed/28282916
http://dx.doi.org/10.3390/ijms18030570

Ejemplares similares