Cargando…

Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5-Formylcytosine Modification in Mitochondrial tRNA(Met)

Human mitochondria contain their own genome, which uses an unconventional genetic code. In addition to the standard AUG methionine codon, the single mitochondrial tRNA Methionine (mt-tRNA(Met)) also recognises AUA during translation initiation and elongation. Post-transcriptional modifications of tR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Van Haute, Lindsey, Powell, Christopher A., Minczuk, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372736/ https://www.ncbi.nlm.nih.gov/pubmed/28257121 http://dx.doi.org/10.3390/biom7010024

Ejemplares similares

YbeY is required for ribosome small subunit assembly and tRNA processing in human mitochondria
por: D’Souza, Aaron R, et al.
Publicado: (2021)

TRMT2B is responsible for both tRNA and rRNA m(5)U-methylation in human mitochondria
por: Powell, Christopher A., et al.
Publicado: (2020)

tRNA Modification and Genetic Code Variations in Animal Mitochondria
por: Watanabe, Kimitsuna, et al.
Publicado: (2011)

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3
por: Van Haute, Lindsey, et al.
Publicado: (2016)

Plant mitochondria use two pathways for the biogenesis of tRNA(His)
por: Placido, Antonio, et al.
Publicado: (2010)

Plant mitochondria use two pathways for the biogenesis of tRNA (His)
por: Placido, Antonio, et al.
Publicado: (2020)

A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome
por: Silva-Pinheiro, Pedro, et al.
Publicado: (2022)

The mammalian mitochondrial epitranscriptome()
por: Rebelo-Guiomar, Pedro, et al.
Publicado: (2019)

METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis
por: Haute, Lindsey Van, et al.
Publicado: (2019)

5-Formylcytosine alters the structure of the DNA double helix
por: Raiber, Eun-Ang, et al.
Publicado: (2014)

The Biogenesis of Mitochondria
por: Weissman, Sherman
Publicado: (1968)

Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships
por: Gackowski, Daniel, et al.
Publicado: (2015)

Base pairing and structural insights into the 5-formylcytosine in RNA duplex
por: Wang, Rui, et al.
Publicado: (2016)

TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies
por: Powell, Christopher A., et al.
Publicado: (2015)

Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
por: Chentsova, Anna, et al.
Publicado: (2014)

Fluorogenic labeling and single-base resolution analysis of 5-formylcytosine in DNA
por: Liu, Chaoxing, et al.
Publicado: (2017)

5-Formylcytosine landscapes of human preimplantation embryos at single-cell resolution
por: Gao, Yun, et al.
Publicado: (2020)

The pH‐Dependence of the Hydration of 5‐Formylcytosine: an Experimental and Theoretical Study
por: Zott, Fabian L., et al.
Publicado: (2022)

Biogenesis and functions of aminocarboxypropyluridine in tRNA
por: Takakura, Mayuko, et al.
Publicado: (2019)

Mitochondrial transcript maturation and its disorders
por: Van Haute, Lindsey, et al.
Publicado: (2015)

Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances
por: Pearce, Sarah F., et al.
Publicado: (2017)

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo
por: Gammage, Payam A., et al.
Publicado: (2018)

tRNA Biology in Mitochondria
por: Salinas-Giegé, Thalia, et al.
Publicado: (2015)

The unconventional biogenesis of Kv7.1-KCNE1 complexes
por: Oliveras, Anna, et al.
Publicado: (2020)

Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles
por: Nigro, Alessandra, et al.
Publicado: (2018)

A common tRNA modification at an unusual location: the discovery of wyosine biosynthesis in mitochondria
por: Sample, Paul J., et al.
Publicado: (2015)

Bisulfite-free and Base-resolution Analysis of 5-formylcytosine at Whole-genome Scale
por: Xia, Bo, et al.
Publicado: (2015)

Unconventional decoding of the AUA codon as methionine by mitochondrial tRNA(Met) with the anticodon f(5)CAU as revealed with a mitochondrial in vitro translation system
por: Takemoto, Chie, et al.
Publicado: (2009)

C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome
por: Rorbach, Joanna, et al.
Publicado: (2012)

C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome
por: Rorbach, Joanna, et al.
Publicado: (2016)

Switching a conflicted bacterial DTD-tRNA code is essential for the emergence of mitochondria
por: Gogoi, Jotin, et al.
Publicado: (2022)

Genetics, biogenesis and bioenergetics of mitochondria
Publicado: (1976)

tRNA-Derived Small RNAs: Biogenesis, Modification, Function and Potential Impact on Human Disease Development
por: Oberbauer, Vera, et al.
Publicado: (2018)

Induction of protein aggregation and starvation response by tRNA modification defects
por: Klassen, Roland, et al.
Publicado: (2020)

Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease
por: Powell, Christopher A., et al.
Publicado: (2015)

RNA modifications stabilize the tertiary structure of tRNA(fMet) by locally increasing conformational dynamics
por: Biedenbänder, Thomas, et al.
Publicado: (2022)

Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion
por: Bruns, Caroline, et al.
Publicado: (2011)

A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
por: Iurlaro, Mario, et al.
Publicado: (2013)

In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine
por: Iurlaro, Mario, et al.
Publicado: (2016)

Impact of 5-formylcytosine on the melting kinetics of DNA by (1)H NMR chemical exchange
por: Dubini, Romeo C A, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7v1dft8g5vutbteeiuks7bdmtt