Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity

Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a h...

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Detalles Bibliográficos
Autores principales: Chen, Yiyuan, Moloney, Jonathan G., Christensen, Kirsten E., Moloney, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372982/
https://www.ncbi.nlm.nih.gov/pubmed/28098784
http://dx.doi.org/10.3390/antibiotics6010002
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author Chen, Yiyuan
Moloney, Jonathan G.
Christensen, Kirsten E.
Moloney, Mark G.
author_facet Chen, Yiyuan
Moloney, Jonathan G.
Christensen, Kirsten E.
Moloney, Mark G.
author_sort Chen, Yiyuan
collection PubMed
description Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity.
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spelling pubmed-53729822017-04-05 Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity Chen, Yiyuan Moloney, Jonathan G. Christensen, Kirsten E. Moloney, Mark G. Antibiotics (Basel) Article Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity. MDPI 2017-01-13 /pmc/articles/PMC5372982/ /pubmed/28098784 http://dx.doi.org/10.3390/antibiotics6010002 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Yiyuan
Moloney, Jonathan G.
Christensen, Kirsten E.
Moloney, Mark G.
Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity
title Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity
title_full Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity
title_fullStr Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity
title_full_unstemmed Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity
title_short Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity
title_sort fused-ring oxazolopyrrolopyridopyrimidine systems with gram-negative activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372982/
https://www.ncbi.nlm.nih.gov/pubmed/28098784
http://dx.doi.org/10.3390/antibiotics6010002
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AT moloneyjonathang fusedringoxazolopyrrolopyridopyrimidinesystemswithgramnegativeactivity
AT christensenkirstene fusedringoxazolopyrrolopyridopyrimidinesystemswithgramnegativeactivity
AT moloneymarkg fusedringoxazolopyrrolopyridopyrimidinesystemswithgramnegativeactivity

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