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When TADs go bad: chromatin structure and nuclear organisation in human disease

Chromatin in the interphase nucleus is organised as a hierarchical series of structural domains, including self-interacting domains called topologically associating domains (TADs). This arrangement is thought to bring enhancers into closer physical proximity with their target genes, which often are...

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Detalles Bibliográficos
Autores principales: Kaiser, Vera B, Semple, Colin A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373421/
https://www.ncbi.nlm.nih.gov/pubmed/28408976
http://dx.doi.org/10.12688/f1000research.10792.1