Cargando…
Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability
Kidney podocytes’ function depends on fingerlike projections (foot processes) that interdigitate with those from neighboring cells to form the glomerular filtration barrier. The integrity of the barrier depends on spatial control of dynamics of actin cytoskeleton in the foot processes. We determined...
Autores principales: | Falkenberg, Cibele V., Azeloglu, Evren U., Stothers, Mark, Deerinck, Thomas J., Chen, Yibang, He, John C., Ellisman, Mark H., Hone, James C., Iyengar, Ravi, Loew, Leslie M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373631/ https://www.ncbi.nlm.nih.gov/pubmed/28301477 http://dx.doi.org/10.1371/journal.pcbi.1005433 |
Ejemplares similares
-
A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction
por: Hu, Mufeng, et al.
Publicado: (2017) -
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
por: Calizo, Rhodora C., et al.
Publicado: (2019) -
Cell shape information is transduced through tension-independent mechanisms
por: Ron, Amit, et al.
Publicado: (2017) -
The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes
por: Casalena, Gabriella A., et al.
Publicado: (2020) -
Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction
por: Xu, Chunmei, et al.
Publicado: (2020)