The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis

The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans. Here, we used the murine CMV (MCMV) model of infection to determine that IFITM3 limits h...

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Detalles Bibliográficos
Autores principales: Stacey, Maria A., Clare, Simon, Clement, Mathew, Marsden, Morgan, Abdul-Karim, Juneid, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Fielding, Ceri A., Smith, Sarah E., Wash, Rachael S., Brias, Silvia Gimeno, Stack, Gabrielle, Notley, George, Cambridge, Emma L., Isherwood, Christopher, Speak, Anneliese O., Johnson, Zoë, Ferlin, Walter, Jones, Simon A., Kellam, Paul, Humphreys, Ian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373880/
https://www.ncbi.nlm.nih.gov/pubmed/28240600
http://dx.doi.org/10.1172/JCI84889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373880/
https://www.ncbi.nlm.nih.gov/pubmed/28240600
http://dx.doi.org/10.1172/JCI84889

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