Structural Equation Modeling of Associations among Taste-Related Risk Factors, Taste Functioning and Adiposity

OBJECTIVE: Variation in taste perception and exposure to risk factors of taste alterations have been independently linked with elevated adiposity. Using a laboratory database, we modeled taste-adiposity associations and examined whether taste functioning mediates the association between taste-related risk factors and adiposity. METHODS: Healthy women (n=407, 35.5±16.9 years) self-reported histories of risk factors of altered taste functioning (tonsillectomy, multiple ear infections, head trauma) and were assessed for taste functioning (tongue-tip and whole-mouth intensities of quinine and salt) and density of taste papillae. Twenty-four percent had elevated waist circumferences; 39% were overweight or had obesity. Using structural equation modeling, we tested direct and indirect associations between taste-related risk factors, taste functioning, and adiposity. RESULTS: In models with good fit, elevated central adiposity was explained directly by history of risk factors (tonsillectomy, multiple ear infections) and directly by lower taste functioning (lower tongue-tip taste function, lower papillae density). Risk factors of taste alterations were significantly associated with lower taste functioning, with taste mediating the association between head trauma and reduced adiposity. CONCLUSION: This large laboratory-based study supports associations between taste-related risk factors, taste functioning and adiposity. Our findings need to be confirmed with other population-based studies, including the NHANES 2013–2014 taste data.