Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA

Adjacent CpG sites in mammalian genomes can be co-methylated due to the processivity of methyltransferases or demethylases. Yet discordant methylation patterns have also been observed, and found related to stochastic or uncoordinated molecular processes. We focused on a systematic search and investi...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Shicheng, Diep, Dinh, Plongthongkum, Nongluk, Fung, Ho-Lim, Zhang, Kang, Zhang, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374016/
https://www.ncbi.nlm.nih.gov/pubmed/28263317
http://dx.doi.org/10.1038/ng.3805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374016/
https://www.ncbi.nlm.nih.gov/pubmed/28263317
http://dx.doi.org/10.1038/ng.3805

Ejemplares similares