Identification of a Potent Allosteric Inhibitor of Human Protein Kinase CK2 by Bacterial Surface Display Library Screening

Human protein kinase CK2 has emerged as promising target for the treatment of neoplastic diseases. The vast majority of kinase inhibitors known today target the ATP binding site, which is highly conserved among kinases and hence leads to limited selectivity. In order to identify non-ATP competitive...

Descripción completa

Detalles Bibliográficos
Autores principales: Nienberg, Christian, Garmann, Claudia, Gratz, Andreas, Bollacke, Andre, Götz, Claudia, Jose, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374410/
https://www.ncbi.nlm.nih.gov/pubmed/28067769
http://dx.doi.org/10.3390/ph10010006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374410/
https://www.ncbi.nlm.nih.gov/pubmed/28067769
http://dx.doi.org/10.3390/ph10010006

Ejemplares similares