Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor †

Protein kinase CK2 is associated with a number of human diseases, among them cancer, and is therefore a target for inhibitor development in industry and academia. Six crystal structures of either CK2α, the catalytic subunit of human protein kinase CK2, or its paralog CK2α′ in complex with two ATP-co...

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Detalles Bibliográficos
Autores principales: Niefind, Karsten, Bischoff, Nils, Golub, Andriy G., Bdzhola, Volodymyr G., Balanda, Anatoliy O., Prykhod’ko, Andriy O., Yarmoluk, Sergiy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374413/
https://www.ncbi.nlm.nih.gov/pubmed/28085026
http://dx.doi.org/10.3390/ph10010009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374413/
https://www.ncbi.nlm.nih.gov/pubmed/28085026
http://dx.doi.org/10.3390/ph10010009

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