Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection

Widespread gene transfer to the retina is challenging as it requires vector systems to overcome physical and biochemical barriers to enter and diffuse throughout retinal tissue. We investigated whether exosome-associated adeno-associated virus, (exo-AAV) enabled broad retinal targeting following int...

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Detalles Bibliográficos
Autores principales: Wassmer, Sarah J., Carvalho, Livia S., György, Bence, Vandenberghe, Luk H., Maguire, Casey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374486/
https://www.ncbi.nlm.nih.gov/pubmed/28361998
http://dx.doi.org/10.1038/srep45329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374486/
https://www.ncbi.nlm.nih.gov/pubmed/28361998
http://dx.doi.org/10.1038/srep45329

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