Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer’s mouse model by controlling β-amyloid production

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a severe and progressive neuronal loss leading to cognitive dysfunctions. Previous reports, based on the use of chemical inhibitors, have connected the stress kinase p38α to neuroinflammation, neuronal death and synaptic dysfu...

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Detalles Bibliográficos
Autores principales: Colié, Sandra, Sarroca, Sara, Palenzuela, Rocío, Garcia, Idoia, Matheu, Ander, Corpas, Rubén, Dotti, Carlos G., Esteban, José A., Sanfeliu, Coral, Nebreda, Angel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374488/
https://www.ncbi.nlm.nih.gov/pubmed/28361984
http://dx.doi.org/10.1038/srep45306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374488/
https://www.ncbi.nlm.nih.gov/pubmed/28361984
http://dx.doi.org/10.1038/srep45306

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