Y14 governs p53 expression and modulates DNA damage sensitivity

Y14 is a core component of the exon junction complex (EJC), while it also exerts cellular functions independent of the EJC. Depletion of Y14 causes G2/M arrest, DNA damage and apoptosis. Here we show that knockdown of Y14 induces the expression of an alternative spliced isoform of p53, namely p53β,...

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Detalles Bibliográficos
Autores principales: Lu, Chia-Chen, Lee, Chi-Chieh, Tseng, Ching-Tzu, Tarn, Woan-Yuh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374521/
https://www.ncbi.nlm.nih.gov/pubmed/28361991
http://dx.doi.org/10.1038/srep45558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374521/
https://www.ncbi.nlm.nih.gov/pubmed/28361991
http://dx.doi.org/10.1038/srep45558

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