Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue

Induced pluripotent stem (iPS) cells hold great potential for being a major source of cells for regenerative medicine. One major issue that hinders their advancement to clinic is the persistence of undifferentiated iPS cells in iPS-derived tissue. In this report, we show that the CDKs inhibitor, Din...

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Detalles Bibliográficos
Autores principales: Alsayegh, Khaled, Matsuura, Katsuhisa, Sekine, Hidekazu, Shimizu, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374522/
https://www.ncbi.nlm.nih.gov/pubmed/28361959
http://dx.doi.org/10.1038/srep45577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374522/
https://www.ncbi.nlm.nih.gov/pubmed/28361959
http://dx.doi.org/10.1038/srep45577

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