Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BACKGROUND: Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer therapeutics. METHODS: In the present work, we re...

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Detalles Bibliográficos
Autores principales: Baburajeev, C. P., Mohan, Chakrabhavi Dhananjaya, Rangappa, Shobith, Mason, Daniel J., Fuchs, Julian E., Bender, Andreas, Barash, Uri, Vlodavsky, Israel, Basappa, Rangappa, Kanchugarakoppal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374561/
https://www.ncbi.nlm.nih.gov/pubmed/28359266
http://dx.doi.org/10.1186/s12885-017-3214-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374561/
https://www.ncbi.nlm.nih.gov/pubmed/28359266
http://dx.doi.org/10.1186/s12885-017-3214-8

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