Revealing common disease mechanisms shared by tumors of different tissues of origin through semantic representation of genomic alterations and topic modeling

BACKGROUND: Cancer is a complex disease driven by somatic genomic alterations (SGAs) that perturb signaling pathways and consequently cellular function. Identifying patterns of pathway perturbations would provide insights into common disease mechanisms shared among tumors, which is important for gui...

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Detalles Bibliográficos
Autores principales: Chen, Vicky, Paisley, John, Lu, Xinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374647/
https://www.ncbi.nlm.nih.gov/pubmed/28361690
http://dx.doi.org/10.1186/s12864-017-3494-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374647/
https://www.ncbi.nlm.nih.gov/pubmed/28361690
http://dx.doi.org/10.1186/s12864-017-3494-z

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