Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment

BACKGROUND: Mitochondria are abundant organelles critical for energy metabolism and brain function. Mitochondrial DNA (mtDNA), released during cellular injury and as part of the innate immune response to viral pathogens, contains CpG motifs that act as TLR-9 ligands. We investigated relationships be...

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Detalles Bibliográficos
Autores principales: Mehta, Sanjay R., Pérez-Santiago, Josué, Hulgan, Todd, Day, Tyler R. C., Barnholtz-Sloan, Jill, Gittleman, Haley, Letendre, Scott, Ellis, Ronald, Heaton, Robert, Patton, Stephanie, Suben, Jesse D., Franklin, Donald, Rosario, Debralee, Clifford, David B., Collier, Ann C., Marra, Christina M., Gelman, Benjamin B., McArthur, Justin, McCutchan, Allen, Morgello, Susan, Simpson, David, Connor, James, Grant, Igor, Kallianpur, Asha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374652/
https://www.ncbi.nlm.nih.gov/pubmed/28359324
http://dx.doi.org/10.1186/s12974-017-0848-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374652/
https://www.ncbi.nlm.nih.gov/pubmed/28359324
http://dx.doi.org/10.1186/s12974-017-0848-z

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