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A statistical method for the conservative adjustment of false discovery rate (q-value)

BACKGROUND: q-value is a widely used statistical method for estimating false discovery rate (FDR), which is a conventional significance measure in the analysis of genome-wide expression data. q-value is a random variable and it may underestimate FDR in practice. An underestimated FDR can lead to une...

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Detalles Bibliográficos
Autor principal: Lai, Yinglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374657/
https://www.ncbi.nlm.nih.gov/pubmed/28361675
http://dx.doi.org/10.1186/s12859-017-1474-6