Cargando…

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

BACKGROUND: Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA elements, acting to determine tissue or cell identity and driving tumor progres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zuber, Verena, Bettella, Francesco, Witoelar, Aree, Andreassen, Ole A., Mills, Ian G., Urbanucci, Alfonso
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374680/ https://www.ncbi.nlm.nih.gov/pubmed/28359301 http://dx.doi.org/10.1186/s12864-017-3620-y

Ejemplares similares

Cross-tissue eQTL enrichment of associations in schizophrenia
por: Bettella, Francesco, et al.
Publicado: (2018)

Towards "biophysical psychiatry": a modeling approach for studying effects of schizophrenia-linked genes on single-neuron excitability
por: Mäki-Marttunen, Tuomo, et al.
Publicado: (2015)

An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies
por: Thompson, Wesley K., et al.
Publicado: (2015)

Identification of shared genetic variants between schizophrenia and lung cancer
por: Zuber, Verena, et al.
Publicado: (2018)

Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci
por: Reppe, Sjur, et al.
Publicado: (2015)

Identification of genetic loci shared between schizophrenia and the Big Five personality traits
por: Smeland, Olav B., et al.
Publicado: (2017)

The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility
por: Leser, Katja, et al.
Publicado: (2012)

Probing the Association between Early Evolutionary Markers and Schizophrenia
por: Srinivasan, Saurabh, et al.
Publicado: (2017)

Discovery and characterization of bromodomain 2–specific inhibitors of BRDT
por: Yu, Zhifeng, et al.
Publicado: (2021)

Recently evolved human-specific methylated regions are enriched in schizophrenia signals
por: Banerjee, Niladri, et al.
Publicado: (2018)

Neural network reconstruction using kinetic Ising models with memory
por: Witoelar, Aree, et al.
Publicado: (2011)

Functional networks of the human bromodomain-containing proteins
por: Gao, Cong, et al.
Publicado: (2022)

Susceptibility Loci Associated with Specific and Shared Subtypes of Lymphoid Malignancies
por: Vijai, Joseph, et al.
Publicado: (2013)

Identification of specific susceptibility loci for the early-onset colorectal cancer
por: Wang, Haoxue, et al.
Publicado: (2023)

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS
por: Wang, Yunpeng, et al.
Publicado: (2016)

The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML
por: Gerlach, Daniel, et al.
Publicado: (2018)

Drug Discovery Targeting Bromodomain-Containing Protein 4
por: Liu, Zhiqing, et al.
Publicado: (2017)

Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis
por: Wang, Ranran, et al.
Publicado: (2020)

Bdf1 Bromodomains Are Essential for Meiosis and the Expression of Meiotic-Specific Genes
por: García-Oliver, Encar, et al.
Publicado: (2017)

Selectivity Mechanism of Pyrrolopyridone Analogues Targeting Bromodomain 2 of Bromodomain-Containing Protein 4 from Molecular Dynamics Simulations
por: Shi, Mingsong, et al.
Publicado: (2023)

Enrichment of genetic markers of recent human evolution in educational and cognitive traits
por: Srinivasan, Saurabh, et al.
Publicado: (2018)

Features of Cryptic Promoters and Their Varied Reliance on Bromodomain-Containing Factors
por: Pattenden, Samantha G., et al.
Publicado: (2010)

Targeting bromodomain-containing proteins: research advances of drug discovery
por: Pan, Zhaoping, et al.
Publicado: (2023)

Identification of novel potent human testis-specific and bromodomain-containing protein (BRDT) inhibitors using crystal structure-based virtual screening
por: GAO, NANA, et al.
Publicado: (2016)

Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci
por: Witoelar, Aree, et al.
Publicado: (2018)

Impact of bromodomain‐containing protein 4 (BRD4) and intestine‐specific homeobox (ISX) expression on the prognosis of patients with hepatocellular carcinoma' for better clarity
por: Chuang, Kai‐Ting, et al.
Publicado: (2021)

Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
por: Drange, Ole Kristian, et al.
Publicado: (2019)

Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors
por: Flynn, Noah R., et al.
Publicado: (2021)

Bromodomain-containing factor GTE4 regulates Arabidopsis immune response
por: Zhou, Qin, et al.
Publicado: (2022)

Mapping vestibular and visual contributions to angular head velocity tuning in the cortex
por: Hennestad, Eivind, et al.
Publicado: (2021)

Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data
por: Polushina, Tatiana, et al.
Publicado: (2017)

Clinical significance of bromodomain-containing protein 7 and its association with tumor progression in prostate cancer
por: Liang, Yong, et al.
Publicado: (2019)

Reduced chromatin accessibility to CD4 T cell super-enhancers encompassing susceptibility loci of rheumatoid arthritis
por: Jadhav, Rohit R., et al.
Publicado: (2022)

CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
por: Fiorito, Elisa, et al.
Publicado: (2016)

Discrimination of candidate subgenome-specific loci by linkage map construction with an S(1) population of octoploid strawberry (Fragaria × ananassa)
por: Nagano, Soichiro, et al.
Publicado: (2017)

Identification of bromodomain-containing protein 4 (BRD4) as a novel marker and epigenetic target in mast cell leukemia
por: Wedeh, Ghaith, et al.
Publicado: (2015)

Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails
por: Huang, Hongda, et al.
Publicado: (2007)

Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins
por: Li, Junlin, et al.
Publicado: (2013)

USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy
por: Wang, Shao-An, et al.
Publicado: (2020)

Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer
por: Cheng, Carol Lai-Hung, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_94loea7okqs8sjlam71akbmgm3