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A computational method for estimating the PCR duplication rate in DNA and RNA-seq experiments
BACKGROUND: PCR amplification is an important step in the preparation of DNA sequencing libraries prior to high-throughput sequencing. PCR amplification introduces redundant reads in the sequence data and estimating the PCR duplication rate is important to assess the frequency of such reads. Existin...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374682/ https://www.ncbi.nlm.nih.gov/pubmed/28361665 http://dx.doi.org/10.1186/s12859-017-1471-9 |