Opposing Intermolecular Tuning of Ca(2+) Affinity for Calmodulin by Neurogranin and CaMKII Peptides

We investigated the impact of bound calmodulin (CaM)-target compound structure on the affinity of calcium (Ca(2+)) by integrating coarse-grained models and all-atomistic simulations with nonequilibrium physics. We focused on binding between CaM and two specific targets, Ca(2+)/CaM-dependent protein...

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Detalles Bibliográficos
Autores principales: Zhang, Pengzhi, Tripathi, Swarnendu, Trinh, Hoa, Cheung, Margaret S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2017
Materias:
Proteins
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374985/
https://www.ncbi.nlm.nih.gov/pubmed/28355539
http://dx.doi.org/10.1016/j.bpj.2017.01.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374985/
https://www.ncbi.nlm.nih.gov/pubmed/28355539
http://dx.doi.org/10.1016/j.bpj.2017.01.020

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