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Opposing Intermolecular Tuning of Ca(2+) Affinity for Calmodulin by Neurogranin and CaMKII Peptides
We investigated the impact of bound calmodulin (CaM)-target compound structure on the affinity of calcium (Ca(2+)) by integrating coarse-grained models and all-atomistic simulations with nonequilibrium physics. We focused on binding between CaM and two specific targets, Ca(2+)/CaM-dependent protein...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374985/ https://www.ncbi.nlm.nih.gov/pubmed/28355539 http://dx.doi.org/10.1016/j.bpj.2017.01.020 |