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Hypersensitive termination of the hypoxic response by a disordered protein switch
The cellular response to hypoxia is critical for cell survival and is fine-tuned to allow cells to recover from hypoxic stress and adapt to heterogeneous or fluctuating oxygen levels(1,2). The hypoxic response is mediated by the α subunit of the transcription factor HIF-1 (HIF-1α)(3), which interact...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375031/ https://www.ncbi.nlm.nih.gov/pubmed/28273070 http://dx.doi.org/10.1038/nature21705 |