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Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen

The origin of ancient ligand/receptor couples is often analyzed via reconstruction of ancient receptors and, when ligands are products of metabolic pathways, they are not supposed to evolve. However, because metabolic pathways are inherited by descent with modification, their structure can be compar...

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Detalles Bibliográficos
Autores principales: Markov, Gabriel V., Gutierrez-Mazariegos, Juliana, Pitrat, Delphine, Billas, Isabelle M. L., Bonneton, François, Moras, Dino, Hasserodt, Jens, Lecointre, Guillaume, Laudet, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375646/
https://www.ncbi.nlm.nih.gov/pubmed/28435861
http://dx.doi.org/10.1126/sciadv.1601778