Transgenic Clustered Regularly Interspaced Short Palindromic Repeat/Cas9-Mediated Viral Gene Targeting for Antiviral Therapy of Bombyx mori Nucleopolyhedrovirus

We developed a novel antiviral strategy by combining transposon-based transgenesis and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system for the direct cleavage of Bombyx mori nucleopolyhedrovirus (BmNPV) genome DNA to promote virus clearance in...

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Detalles Bibliográficos
Autores principales: Chen, Shuqing, Hou, Chengxiang, Bi, Honglun, Wang, Yueqiang, Xu, Jun, Li, Muwang, James, Anthony A., Huang, Yongping, Tan, Anjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Cellular Response to Infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375672/
https://www.ncbi.nlm.nih.gov/pubmed/28122981
http://dx.doi.org/10.1128/JVI.02465-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375672/
https://www.ncbi.nlm.nih.gov/pubmed/28122981
http://dx.doi.org/10.1128/JVI.02465-16

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