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Transgenic Clustered Regularly Interspaced Short Palindromic Repeat/Cas9-Mediated Viral Gene Targeting for Antiviral Therapy of Bombyx mori Nucleopolyhedrovirus
We developed a novel antiviral strategy by combining transposon-based transgenesis and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system for the direct cleavage of Bombyx mori nucleopolyhedrovirus (BmNPV) genome DNA to promote virus clearance in...
Autores principales: | Chen, Shuqing, Hou, Chengxiang, Bi, Honglun, Wang, Yueqiang, Xu, Jun, Li, Muwang, James, Anthony A., Huang, Yongping, Tan, Anjiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375672/ https://www.ncbi.nlm.nih.gov/pubmed/28122981 http://dx.doi.org/10.1128/JVI.02465-16 |
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