Cargando…

Developing Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor

Urea transporter B (UT-B) is a membrane channel protein that specifically transports urea. UT-B null mouse exhibited urea selective urine concentrating ability deficiency, which suggests the potential clinical applications of the UT-B inhibitors as novel diuretics. Primary high-throughput virtual sc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Min, Tou, Weng Ieong, Zhou, Hong, Li, Fei, Ren, Huiwen, Chen, Calvin Yu-Chian, Yang, Baoxue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376056/ https://www.ncbi.nlm.nih.gov/pubmed/25047372 http://dx.doi.org/10.1038/srep05775

Ejemplares similares

In Silico Investigation of Potential Src Kinase Ligands from Traditional Chinese Medicine
por: Tou, Weng Ieong, et al.
Publicado: (2012)

Expression of Urea Transporter B in Normal and Injured Brain
por: Huang, Boyue, et al.
Publicado: (2021)

Urea Transporter Physiology Studied in Knockout Mice
por: Li, Xuechen, et al.
Publicado: (2012)

Urea Transporter Inhibitor 25a Reduces Ascites in Cirrhotic Rats
por: Ying, Yi, et al.
Publicado: (2023)

Preclinical Pharmacokinetic Studies of a Novel Diuretic Inhibiting Urea Transporters
por: Xu, Yue, et al.
Publicado: (2022)

Drug Design for Neuropathic Pain Regulation from Traditional Chinese Medicine
por: Tou, Weng Ieong, et al.
Publicado: (2013)

Identification of a Novel UT-B Urea Transporter in Human Urothelial Cancer
por: Hou, Ruida, et al.
Publicado: (2017)

Physiological functions of urea transporter B
por: Yu, Lanying, et al.
Publicado: (2019)

Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway
por: Sun, Yi, et al.
Publicado: (2016)

Urea Transporter UT-B Deletion Induces DNA Damage and Apoptosis in Mouse Bladder Urothelium
por: Dong, Zixun, et al.
Publicado: (2013)

Discovery of novel diarylamides as orally active diuretics targeting urea transporters
por: Zhang, Shun, et al.
Publicado: (2021)

Structural characterization of human urea transporters UT-A and UT-B and their inhibition
por: Chi, Gamma, et al.
Publicado: (2023)

A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters
por: Li, Min, et al.
Publicado: (2019)

Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats
por: Cil, Onur, et al.
Publicado: (2015)

Elevated urinary urea by high-protein diet could be one of the inducements of bladder disorders
por: Liu, Ming, et al.
Publicado: (2016)

Localization of urea transporter B in the developing bovine rumen
por: Zhong, Chongliang, et al.
Publicado: (2022)

Hypothetical membrane mechanisms in essential tremor
por: Shaikh, Aasef G, et al.
Publicado: (2008)

Water transport mediated by murine urea transporters: implications for urine concentration mechanisms
por: Kabutomori, J., et al.
Publicado: (2020)

Mechanisms of molecular transport through the urea channel of Helicobacter pylori
por: McNulty, Reginald, et al.
Publicado: (2013)

Energetic and Molecular Water Permeation Mechanisms of the Human Red Blood Cell Urea Transporter B
por: Azouzi, Slim, et al.
Publicado: (2013)

Regional investigation of UT-B urea transporters in the rat brain
por: Pinki, Farhana, et al.
Publicado: (2023)

Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism
por: Poh, Sharon Shuxian, et al.
Publicado: (2016)

The Hypothetical Rabbit
por: Kattan, Michael W.
Publicado: (2016)

Urea transporters and sweat response to uremia
por: Keller, Raymond W., et al.
Publicado: (2016)

Examining industrial air pollution embodied in trade: implications of a hypothetical China-UK FTA
por: Zhang, Yuquan W., et al.
Publicado: (2022)

The role of rumen epithelial urea transport proteins in urea nitrogen salvage: A review
por: Zhong, Chongliang, et al.
Publicado: (2022)

MECHANISM OF UREA EXCRETION
por: Oliver, Jean
Publicado: (1921)

Urea transport and hydrolysis in the rumen: A review
por: Hailemariam, Samson, et al.
Publicado: (2021)

Hypothetical COVID-19 protection mechanism: hints from centenarians
por: Guerini, Franca Rosa, et al.
Publicado: (2021)

Neurological Mechanisms of Animal-Assisted Intervention in Alzheimer’s Disease: A Hypothetical Review
por: Kim, Sujin, et al.
Publicado: (2021)

Hypothetical thinking : dual processes in reasoning and judgement
por: Evans, Jonathan St. B. T., 1948-
Publicado: (2007)

Sex-Related Differences in UT-B Urea Transporter Abundance in Fallow Deer Rumen
por: Zhong, Chongliang, et al.
Publicado: (2022)

Filling gaps in metabolism using hypothetical reactions
por: Li, Feiran
Publicado: (2022)

Hypothetical Interventions for Falls Among Older Adults: An Application of the Parametric G-Formula
por: Ren, Jiaojiao, et al.
Publicado: (2021)

Ammonium and Urea Transporter Inventory of the Selaginella and Physcomitrella Genomes
por: De Michele, Roberto, et al.
Publicado: (2012)

Investigation of facilitative urea transporters in the human gastrointestinal tract
por: Walpole, Caragh, et al.
Publicado: (2018)

Genomics of Urea Transport and Catabolism in Cyanobacteria: Biotechnological Implications
por: Veaudor, Théo, et al.
Publicado: (2019)

Competition continues for hypothetical particle
Publicado: (2009)

THE MECHANISM OF UREA RETENTION IN NEPHRITIS
por: McLean, Franklin C.
Publicado: (1917)

The Relation between Ouabain-Sensitive Potassium Efflux and the Hypothetical Dephosphorylation Step in the "Transport ATPase" System
por: Glynn, I. M., et al.
Publicado: (1968)

Cannot write session to /tmp/vufind_sessions/sess_s37gig20rv3oeisdq1gdv51n45