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Characterizing the pocketome of Mycobacterium tuberculosis and application in rationalizing polypharmacological target selection
Polypharmacology is beginning to emerge as an important concept in the field of drug discovery. However, there are no established approaches to either select appropriate target sets or design polypharmacological drugs. Here, we propose a structural-proteomics approach that utilizes the structural in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376175/ https://www.ncbi.nlm.nih.gov/pubmed/25220818 http://dx.doi.org/10.1038/srep06356 |