Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src away from focal adhesions into autophagic structures t...

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Detalles Bibliográficos
Autores principales: Schoenherr, Christina, Byron, Adam, Sandilands, Emma, Paliashvili, Ketevan, Baillie, George S, Garcia-Munoz, Amaya, Valacca, Cristina, Cecconi, Francesco, Serrels, Bryan, Frame, Margaret C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376188/
https://www.ncbi.nlm.nih.gov/pubmed/28362576
http://dx.doi.org/10.7554/eLife.23172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376188/
https://www.ncbi.nlm.nih.gov/pubmed/28362576
http://dx.doi.org/10.7554/eLife.23172

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