Cargando…

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src away from focal adhesions into autophagic structures t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schoenherr, Christina, Byron, Adam, Sandilands, Emma, Paliashvili, Ketevan, Baillie, George S, Garcia-Munoz, Amaya, Valacca, Cristina, Cecconi, Francesco, Serrels, Bryan, Frame, Margaret C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376188/ https://www.ncbi.nlm.nih.gov/pubmed/28362576 http://dx.doi.org/10.7554/eLife.23172

Ejemplares similares

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells
por: Schoenherr, Christina, et al.
Publicado: (2014)

p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy
por: Sandilands, Emma, et al.
Publicado: (2015)

FAK and talin: Who is taking whom to the integrin engagement party?
por: Serrels, Bryan, et al.
Publicado: (2012)

Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression
por: Pourpirali, Somayeh, et al.
Publicado: (2015)

Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar
por: Su, Linlin, et al.
Publicado: (2016)

Src controls castration recurrence of CWR22 prostate cancer xenografts
por: Su, Bing, et al.
Publicado: (2013)

RhoA and Membrane Fluidity Mediates the Spatially Polarized Src/FAK Activation in Response to Shear Stress
por: Liu, Bo, et al.
Publicado: (2014)

FAK competes for Src to promote migration against invasion in melanoma cells
por: Kolli-Bouhafs, K, et al.
Publicado: (2014)

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3
por: Lee, Jaewon J., et al.
Publicado: (2018)

MMP-11 promoted the oral cancer migration and FAK/Src activation
por: Hsin, Chung-Han, et al.
Publicado: (2017)

FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs
por: Griffith, Billie G. C., et al.
Publicado: (2021)

Visualization of Src and FAK Activity during the Differentiation Process from HMSCs to Osteoblasts
por: Liao, Xiaoling, et al.
Publicado: (2012)

The dual kinase complex FAK-Src as a promising therapeutic target in cancer
por: Bolós, Victoria, et al.
Publicado: (2010)

The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET
por: Liao, Xiaoling, et al.
Publicado: (2013)

Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition
por: Horton, Edward R., et al.
Publicado: (2016)

c-Src drives intestinal regeneration and transformation
por: Cordero, Julia B, et al.
Publicado: (2014)

Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking
por: Arnette, Christopher, et al.
Publicado: (2016)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
por: Wang, Wenqi, et al.
Publicado: (2011)

MICA Expression Is Regulated by Cell Adhesion and Contact in a FAK/Src-Dependent Manner
por: Moncayo, Gerald, et al.
Publicado: (2017)

Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation
por: Wang, Jing, et al.
Publicado: (2017)

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity
por: Canel, Marta, et al.
Publicado: (2020)

Dissociation of FAK/p130(CAS)/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK
por: Yamakita, Yoshihiko, et al.
Publicado: (1999)

mTOR, AMBRA1, and autophagy: An intricate relationship
por: Nazio, Francesca, et al.
Publicado: (2013)

Epithelial Membrane Protein-2 Promotes Endometrial Tumor Formation through Activation of FAK and Src
por: Fu, Maoyong, et al.
Publicado: (2011)

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition
por: Wilson, Catherine, et al.
Publicado: (2014)

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway
por: Kim, Nam-Gyun, et al.
Publicado: (2015)

An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer
por: Tai, Yu-Ling, et al.
Publicado: (2015)

Shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of Src and FAK
por: HAO, ZHENFENG, et al.
Publicado: (2015)

CD151 mediates netrin‐1‐induced angiogenesis through the Src‐FAK‐Paxillin pathway
por: Yang, Xiaosheng, et al.
Publicado: (2016)

Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines
por: Chikara, Shireen, et al.
Publicado: (2017)

c-CBL regulates melanoma proliferation, migration, invasion and the FAK-SRC-GRB2 nexus
por: Nihal, Minakshi, et al.
Publicado: (2016)

Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity
por: Gayrard, Charlène, et al.
Publicado: (2018)

Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest
por: Roycroft, Alice, et al.
Publicado: (2018)

Scutellarin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF/ERK/FAK/Src Pathway Signaling
por: Long, Lingli, et al.
Publicado: (2019)

Desmoglein 3 contributes to tumorigenicity of pancreatic ductal adenocarcinoma through activating Src–FAK signaling
por: Abula, Yimamumaimaitijiang, et al.
Publicado: (2021)

IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAK
por: Lehman, Christine E., et al.
Publicado: (2021)

Targeting the FAK-Src Complex in Desmoplastic Small Round Cell Tumors, Ewing Sarcoma, and Rhabdomyosarcoma
por: van Erp, Anke E. M., et al.
Publicado: (2022)

Zebrafish ambra1a and ambra1b Knockdown Impairs Skeletal Muscle Development
por: Skobo, Tatjana, et al.
Publicado: (2014)

Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila
por: Nishida, Hiroshi, et al.
Publicado: (2021)

Connecting autophagy: AMBRA1 and its network of regulation
por: Cianfanelli, Valentina, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_v80jg460tmr89v2jvb3o9fat7u