The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells

Self-renewing naïve mouse embryonic stem cells (mESCs) contain few mitochondria, which increase in number and volume at the onset of differentiation. KBP (encoded by Kif1bp) is an interactor of the mitochondrial-associated kinesin Kif1Bα. We found that TDH, responsible for mitochondrial production o...

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Detalles Bibliográficos
Autores principales: Donato, Valerio, Bonora, Massimo, Simoneschi, Daniele, Sartini, Davide, Kudo, Yasusei, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Stadtfeld, Matthias, Pinton, Paolo, Pagano, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376241/
https://www.ncbi.nlm.nih.gov/pubmed/28319092
http://dx.doi.org/10.1038/ncb3491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376241/
https://www.ncbi.nlm.nih.gov/pubmed/28319092
http://dx.doi.org/10.1038/ncb3491

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