Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum

Chloroquine, long the default first-line treatment against malaria, is now abandoned in large parts of the world because of widespread drug-resistance in Plasmodium falciparum. In spite of its importance as a cost-effective and efficient drug, a coherent understanding of the cellular mechanisms affe...

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Detalles Bibliográficos
Autores principales: Tewari, Shivendra G., Prigge, Sean T., Reifman, Jaques, Wallqvist, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376308/
https://www.ncbi.nlm.nih.gov/pubmed/28355531
http://dx.doi.org/10.1016/j.ijpddr.2017.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376308/
https://www.ncbi.nlm.nih.gov/pubmed/28355531
http://dx.doi.org/10.1016/j.ijpddr.2017.03.004

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