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Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum
Chloroquine, long the default first-line treatment against malaria, is now abandoned in large parts of the world because of widespread drug-resistance in Plasmodium falciparum. In spite of its importance as a cost-effective and efficient drug, a coherent understanding of the cellular mechanisms affe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376308/ https://www.ncbi.nlm.nih.gov/pubmed/28355531 http://dx.doi.org/10.1016/j.ijpddr.2017.03.004 |