Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Ra...

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Detalles Bibliográficos
Autores principales: Luck, Christian, DeMarco, Vincent G., Mahmood, Abuzar, Gavini, Madhavi P., Pulakat, Lakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376943/
https://www.ncbi.nlm.nih.gov/pubmed/28408970
http://dx.doi.org/10.1155/2017/5724046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376943/
https://www.ncbi.nlm.nih.gov/pubmed/28408970
http://dx.doi.org/10.1155/2017/5724046

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