Discovery of novel inhibitors of human S-adenosylmethionine decarboxylase based on in silico high-throughput screening and a non-radioactive enzymatic assay

Natural polyamines are small polycationic molecules essential for cell growth and development, and elevated level of polyamines is positively correlated with various cancers. As a rate-limiting enzyme of the polyamine biosynthetic pathway, S-adenosylmethionine decarboxylase (AdoMetDC) has been an at...

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Detalles Bibliográficos
Autores principales: Liao, Chenzeng, Wang, Yanlin, Tan, Xiao, Sun, Lidan, Liu, Sen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377238/
https://www.ncbi.nlm.nih.gov/pubmed/26030749
http://dx.doi.org/10.1038/srep10754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377238/
https://www.ncbi.nlm.nih.gov/pubmed/26030749
http://dx.doi.org/10.1038/srep10754

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